Semmelweis
Who is Semmelweis?
Semmelweis is a 6-star Mineral-afflatus, Reality-damage damage-buffing Support with a vampire theme — she drains the HP of her allies in exchange for potent offensive buffs (prydwen rating 10). Through [Fresh Blood], [Blood Domain] and [Truth Revealed] she grants powerful DMG Bonus and Crit Rate buffs, and can apply [Fresh Blood] to herself for a personal-DPS playstyle. She was free during Version 1.9. Source: prydwen.gg/re1999/characters/semmelweis.
Kit Summary
6★ Mineral · Reality DMG · damage-buffing Support; tags Support, DPS, Blood Burn. Source: prydwen.
Drains ally HP via [Fresh Blood] / [Blood Domain] to grant powerful DMG Bonus and Crit Rate buffs.
Her buff Array stacks with other status effects and is simple to maintain.
Accumulates over time to scale her effect.
Can apply [Fresh Blood] to herself for a high-multiplier personal-damage playstyle.
Build Guide
🔮 Best Relic / Echo Set
Resonance: Euphoria Bloodtithe Support pattern (R10 Equibalance) balancing Critical Rate / Crit DMG with Max HP; pre-Euphoria use Incantation Might / DMG Bonus. Portray: P1 for the early spike. Source: prydwen.
⚔ Best Light Cone / Weapon
The Third Commitment (best-in-slot — prydwen first). Alternatives in order (prydwen): Into the Gentle Current; From The Depths; Ready on Call; Long Night Talk; In the Shadow.
📊 Substats Priority
👥 Best Teams
Universal buff support — pair her with self-damaging or HP-flexible carries who benefit from her DMG Bonus / Crit Rate Array. Run her with a strong carry plus a dedicated healer to offset the HP tax, and a flex slot. (Synergy framing per prydwen; full comp is editorial.)
F2P Verdict
Semmelweis was free during Version 1.9, making her widely accessible. Her signature The Third Commitment is best-in-slot, but Into the Gentle Current, From The Depths, Ready on Call, Long Night Talk and In the Shadow are listed alternatives. Her HP drain requires substantial sustain on the team. Source: prydwen.
Frequently Asked Questions
Is Semmelweis good in Reverse: 1999?
Yes — prydwen rates her 10. She is a universal damage-buffing support who drains ally HP for powerful DMG Bonus and Crit Rate buffs via [Fresh Blood] and [Blood Domain], with a stackable Array and the option to deal strong personal damage herself.
What is the best psychube for Semmelweis?
The Third Commitment is her best-in-slot on prydwen. Alternatives, in order, are Into the Gentle Current, From The Depths, Ready on Call, Long Night Talk, and In the Shadow.
Is Semmelweis F2P-friendly?
Yes — she was given free during Version 1.9, so many accounts already own her, and she works without her signature psychube. The main cost is team-building: her HP drain requires a solid healer to keep the team safe.
Should I pull Semmelweis?
If she is available, yes — she is a top-tier universal buffer (prydwen rating 10). Just plan your team around the HP tax by running reliable sustain, and pair her with carries who like the DMG Bonus and Crit Rate buffs.